The search for more effective and safer therapies remains a fundamental challenge in oncology. For the first time, this research led by Sara Cuadrado-Castaño demonstrates the therapeutic potential of certain avulaviruses other than Newcastle Disease Virus (NDV). The most relevant being Avian Paramyxovirus 4 (APMV-4) in murine models of melanoma and colorectal cancer, two highly aggressive tumors, due to intratumoral administration of APMV-4 achieved complete remissions, significantly prolonged survival, and, importantly, induced long-term antitumor immune memory, providing protection against tumor relapse.
These findings establish APMV-4 as a strongest oncolytic candidate capable of overcoming the limitations of previously employed viruses and leads to new possibilities for the development of advanced virotherapies in cancer.
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